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What Are Nootropics? Whether you're a college student hoping to ace your exams, a busy professional striving for a promotion, or an older adult concerned about dementia, the idea of popping a pill that boosts your brainpower might seem pretty appealing. So perhaps it's not surprising that the use of nootropics — aka cognitive enhancers or smart drugs — is on the rise. ; The term "nootropics" first referred to chemicals that met very specific criteria. But now it's used to refer to any natural or synthetic substance that may have a positive impact on mental skills. In general, nootropics fall into three general categories: dietary supplements, synthetic compounds, and prescription drugs. While health experts generally agree that taking a prescription nootropic for an FDA-approved purpose (such as a stimulant medication if you have ADHD or donepezil if you have Alzheimer's) may be helpful, the use of any type of cognitive enhancer in healthy people is far more controversial.